{"id":3979,"date":"2025-11-27T18:26:41","date_gmt":"2025-11-27T17:26:41","guid":{"rendered":"https:\/\/www.bactechnology.it\/en\/?p=3979"},"modified":"2025-11-28T11:34:21","modified_gmt":"2025-11-28T10:34:21","slug":"sirio-lipus-bac-technology-nello-studio-italiano-che-apre-nuove-strade-contro-le-malattie-infiammatorie-croniche","status":"publish","type":"post","link":"https:\/\/www.bactechnology.it\/en\/sirio-lipus-bac-technology-nello-studio-italiano-che-apre-nuove-strade-contro-le-malattie-infiammatorie-croniche\/","title":{"rendered":"Sirio (LIPUS) Bac Technology in the study that opens new avenues against chronic inflammatory diseases"},"content":{"rendered":"<p data-start=\"143\" data-end=\"788\">A beam of low-intensity pulsed ultrasound, beating like a tiny invisible drum, may become a new ally in the treatment of inflammatory bowel diseases. This is the promise emerging from the work of a multicenter Italian research team \u2013 involving institutions such as Humanitas, Sant\u2019Anna School of Advanced Studies in Pisa, Universit\u00e0 Cattolica, and the company BAC Technology \u2013 which explored the effects of <a href=\"https:\/\/www.bactechnology.it\/en\/sirio\/#\" target=\"_blank\" rel=\"noopener\"><strong data-start=\"660\" data-end=\"724\">SIRIO Bac Technology Low-Intensity Pulsed Ultrasound (LIPUS)<\/strong><\/a> on inflamed mucosal tissue in an experimental model of colitis.<\/p>\n<p data-start=\"790\" data-end=\"1222\">This research, titled <strong data-start=\"812\" data-end=\"939\">\u201cLow-Intensity Pulsed Ultrasound as a Biophysical Modality to Assess and Modulate Mucosal Activity in Experimental Colitis\u201d<\/strong>, will be presented at the <strong data-start=\"966\" data-end=\"1030\">21st ECCO Congress (European Crohn&#8217;s &amp; Colitis Organisation)<\/strong> in Stockholm, Sweden, from February 21 to 26, 2026 (authors: B. Ricchi, S.E. Pineda Chavez, M. Wozny, G. Mori, T. Pratellesi, D. Lucchetti, A. Sgambato, A. Cafarelli, L. Ricotti, S. Vetrano).<\/p>\n<p data-start=\"1224\" data-end=\"1637\">The <a href=\"https:\/\/www.bactechnology.it\/en\/sirio\/#\" target=\"_blank\" rel=\"noopener\"><strong data-start=\"1228\" data-end=\"1258\">SIRIO Bac Technology LIPUS<\/strong><\/a> device is known for its regenerative and anti-inflammatory capabilities across various tissues, yet no one had seriously investigated what it might do in the context of a diseased intestine. The question was simple and ambitious: can a micrometric \u201cmechanical push\u201d interact with the mucosa and dampen inflammation? The researchers\u2019 findings point surprisingly close to a \u201cyes.\u201d<\/p>\n<p data-start=\"1224\" data-end=\"1637\"><strong data-start=\"1647\" data-end=\"1684\">The beneficial wave of ultrasound<\/strong><\/p>\n<p data-start=\"1686\" data-end=\"1730\">The data revealed a striking set of effects:<\/p>\n<p data-start=\"1732\" data-end=\"1793\">\u2b50 <strong>1. A single stimulation outperforms repeated sessions<\/strong><\/p>\n<p data-start=\"1794\" data-end=\"1953\">Just one exposure more effectively improved body weight, disease activity index, and colon length compared to controls \u2014 a kind of \u201cjust-in-time\u201d intervention.<\/p>\n<p data-start=\"1955\" data-end=\"1995\">\u2b50 <strong>2. Inflammation quickly subsides<\/strong><\/p>\n<p data-start=\"1996\" data-end=\"2148\">At 2, 24, and 96 hours after stimulation, researchers observed a significant decrease in pro-inflammatory cytokines:<br data-start=\"2112\" data-end=\"2115\" \/><strong data-start=\"2115\" data-end=\"2147\">TNF-\u03b1, IL-1\u03b2, IFN-\u03b3 (P&lt;0.05)<\/strong>.<\/p>\n<p data-start=\"2150\" data-end=\"2184\">\u2b50<strong> 3. Immune cells reorganize<\/strong><\/p>\n<p data-start=\"2185\" data-end=\"2220\">The <a href=\"https:\/\/www.bactechnology.it\/en\/sirio\/#\" target=\"_blank\" rel=\"noopener\"><strong data-start=\"2189\" data-end=\"2219\">SIRIO Bac Technology LIPUS<\/strong><\/a>:<\/p>\n<ul data-start=\"2222\" data-end=\"2449\">\n<li data-start=\"2222\" data-end=\"2273\">\n<p data-start=\"2224\" data-end=\"2273\">reduces inflammatory cell infiltration (CD45+),<\/p>\n<\/li>\n<li data-start=\"2274\" data-end=\"2354\">\n<p data-start=\"2276\" data-end=\"2354\">promotes macrophage switching toward a reparative M2 profile (CD68+\/CD163+),<\/p>\n<\/li>\n<li data-start=\"2355\" data-end=\"2449\">\n<p data-start=\"2357\" data-end=\"2449\">accelerates restoration of mucosal barrier integrity as early as <strong data-start=\"2422\" data-end=\"2448\">2 hours post-treatment<\/strong>.<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"2451\" data-end=\"2520\">\u2b50 <strong>4. <a href=\"https:\/\/www.bactechnology.it\/en\/sirio\/#\" target=\"_blank\" rel=\"noopener\">LIPUS<\/a>-induced vesicles act as anti-inflammatory messengers<\/strong><\/p>\n<p data-start=\"2521\" data-end=\"2761\">Extracellular vesicles (EVs) extracted from treated mice and intravenously transferred into colitic animals reduced circulating TNF-\u03b1 levels, suggesting that part of the LIPUS effect may travel through these microscopic biological couriers.<\/p>\n<p data-start=\"2768\" data-end=\"2812\"><strong data-start=\"2771\" data-end=\"2812\">An unprecedented therapeutic scenario<\/strong><\/p>\n<p data-start=\"2768\" data-end=\"2812\">According to the authors, <a href=\"https:\/\/www.bactechnology.it\/en\/sirio\/#\" target=\"_blank\" rel=\"noopener\"><strong data-start=\"2840\" data-end=\"2870\">SIRIO Bac Technology LIPUS<\/strong><\/a> emerges as a safe, non-invasive approach capable of modulating inflammation with a speed rarely achievable through traditional therapies. The data are preliminary and require further confirmation, but they open a compelling path: a <strong data-start=\"3103\" data-end=\"3137\">physical, gut-targeted therapy<\/strong> capable of influencing the immune response both locally and systemically.<\/p>\n<p data-start=\"3213\" data-end=\"3318\">In other words, a millimetric mechanical wave whispering to damaged tissue a way back toward equilibrium.<\/p>\n<p data-start=\"3325\" data-end=\"3403\"><strong data-start=\"3328\" data-end=\"3403\">The horizon: bringing <a href=\"https:\/\/www.bactechnology.it\/en\/sirio\/#\" target=\"_blank\" rel=\"noopener\">SIRIO Bac Technology LIPUS<\/a> into clinical practice<\/strong><\/p>\n<p data-start=\"3405\" data-end=\"3811\">This study lays the groundwork for broader investigations and future clinical applications in <strong data-start=\"3499\" data-end=\"3536\">inflammatory bowel diseases (IBD)<\/strong>, such as ulcerative colitis and Crohn\u2019s disease. If confirmed in humans, <a href=\"https:\/\/www.bactechnology.it\/en\/sirio\/#\" target=\"_blank\" rel=\"noopener\"><strong data-start=\"3610\" data-end=\"3640\">SIRIO Bac Technology LIPUS<\/strong><\/a> may evolve into a new therapeutic frontier, complementary to biologic agents and conventional treatments, thanks to its ability to modulate the mucosa without harming it.<\/p>\n<p data-start=\"3813\" data-end=\"4021\">An innovation at the crossroads of biomechanics, immunology, and regenerative medicine \u2014 a rare convergence of disciplines that, in this case, might truly shift the trajectory of intestinal inflammation care.<\/p>\n<p data-start=\"4028\" data-end=\"4575\">(Humanitas University, Department of Biomedical Sciences, Milan, Italy.<br data-start=\"4101\" data-end=\"4104\" \/>IRCCS Humanitas Research Hospital, Laboratory of Gastroenterology \u2013 Department of Gastroenterology, Milan, Italy.<br data-start=\"4217\" data-end=\"4220\" \/>BAC Technology srl, Florence, Italy.<br data-start=\"4256\" data-end=\"4259\" \/>Universit\u00e0 Cattolica del Sacro Cuore, Department of Translational Medicine and Surgery, Rome, Italy.<br data-start=\"4359\" data-end=\"4362\" \/>Fondazione Policlinico Universitario \u201cAgostino Gemelli\u201d IRCCS, Rome, Italy.<br data-start=\"4437\" data-end=\"4440\" \/>Sant\u2019Anna School of Advanced Studies, Department of Excellence in Robotics &amp; AI \u2013 Regenerative Technologies Laboratory, Pisa, Italy.)<\/p>\n<p data-start=\"4577\" data-end=\"4629\">(November, 27 2025) \u00a9 Press Office Bac Technology<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A beam of low-intensity pulsed ultrasound, beating like a tiny invisible drum, may become a new ally in the treatment [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":3981,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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